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The functional form of the logistic function when centered at 50 points would mean that those ASM participants with final scores within the top 25 percent and the bottom 25 percent of final scores would receive relatively similar ASM payment adjustment factors

10.3389/fphar.2019.00376 33 LiS

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2) and the MM-like expression derived from our formulation clarify that phosphorylation and -arrestin binding are the two main processes responsible for shaping a drug tolerance (a suppressed downstream signaling at high agonist concentration), a dose-response widely observed in biochemical assays (Fig