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NAPQI Formation Highest in FIRST Trimester 43% HIGHER The same Brookhuis 2021 study found: The estimated molar dose fraction of NAPQI was the highest in the first trimester (median (IQR): 11 (9.113.4%), followed by the second (9.0 (7.511%)) and third (8.2 (6.810.1)) trimester compared with non-pregnant women (7.7 (6.49.4%)).[] **This represents a 43% INCREASE in toxic NAPQI formation in the first trimester** (11% vs 7.7%)precisely when the fetal brain is most vulnerable and undergoing critical early development
DNA damage promotes mutations of suppressor in tumor such as calcium/calmodulin dependent serine protein kinase (CASK), p53, as well as stimulation of the epidermal growth factor receptor (EFGR) signaling pathway, which are important early events in gastric carcinogenesis (86, 87)
Hruska, P
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