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This observation is wholly consistent with a simple steric mechanism for SpyCatcher inhibition in the modified form of these 6 cysteine mutants

What we're seeing across the trials: Reduced cardiovascular mortality Decreased stroke risk Lower heart failure hospitalisation rates Here's what matters most: These benefits go BEYOND what we'd expect from weight loss or glycaemic control alone

Don't forget to gently shake before use and then take 2ml per day

To minimize the impact of bias, we included both male and female mice (mutants and respective gender controls) in the different experiments, as reported in the figure legends