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another barrier-enhancing mechanism is where Akkermansia induces Paneth cells to produce antimicrobial peptides, and SCFAs from intestinal mucin glycoproteins are absorbed in the colon as an energy source for colonic cells, inducing regulatory T cells and exerting anti-inflammatory effects (Reunanen et al., 2015

In rats, R -lipoic acid was more effective than S -lipoic acid in enhancing insulin-stimulated glucose transport and metabolism in skeletal muscle (110), and R -lipoic acid was more effective than R,S -lipoic acid and S -lipoic acid in preventing cataracts (111)

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