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76,77 In summary, disc cells respond to altered loads and osmotic pressures, to DAMPs, MMPs and pro-inflammatory cytokines with the expression of catabolic enzymes, with anabolic healing attempts, and with inflammation resulting in failed healing attempts, damage accumulation and chronic inflammation leading eventually to DD

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All experiments were conducted in accordance with Gubra Aps bioethical guidelines, which were fully compliant with internationally accepted principles for the care and use of laboratory animals