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This therapeutic effect was mechanistically linked to reductions in pro-inflammatory cytokines (TNF-, IL-1), enhancement of antioxidant defenses (e.g., increased superoxide dismutase activity), suppression of apoptosis via caspase-3 inhibition, and modulation of NF-B pathwayscollectively yielding neuroprotection and symptomatic relief ( Curcumin shows therapeutic potential for managing peripheral neuropathic pain through multiple mechanisms (Basu et al., 2021)

Correction of CFTR malfunction and stimulation of Ca-activated Cl channels restore HCO3- secretion in cystic fibrosis bile ductular cells

Before starting any new supplement regimen, it's advisable to consult with a healthcare professional, who can provide guidance based on your specific health needs and conditions

Kang R, Zeng L, Zhu S, Xie Y, Liu J, Wen Q, et al