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They have a resembling role as supporting cells, as they wrap around type II and III cells, forming lamellar processes that may facilitate the degradation of neurotransmitters, and also creating the independent clusters of each TBC (40, 41)

GLP-1R expressing cells are widely expressed in mouse and non-human primate brain (Heppner et al., 2015)

However, sustained 2-year weight loss with liraglutide 3.0 mg treatment as an adjunct to diet and exercise has previously been demonstrated in obese individuals without T2DM

Effects of Once-Weekly Semaglutide on Appetite, Energy Intake, Control of Eating, Food Preference and Body Weight in Subjects With Obesity