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Hypoglycaemia patients receiving GLP-1 and GIP analogues therapy alongside sulfonylureas or insulin therapy may have an increased risk of adverse effects[511]

The DCCT study demonstrated that intensive insulin therapy in T1D significantly reduced the risk of DPN by 64% and cardiovascular autonomic neuropathy by 45% compared with conventional treatment, with these benefits persisting for over 13 years after the trial ended [60]

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