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GLP-1 potentiates glucose-induced insulin secretion, suppresses glucagon release, slows gastric emptying and may serve as a satiation signal, although the physiological status of the latter function has not been fully established yet

Finally, dexamethasone was conjugated with GLP-1 and this peptide induced weight loss in obese mice with a greater efficiency than GLP-1 alone [103]

Samples were stored at 80 C until further use

This addition allows the peptide to bind to albumin, a transporter protein commonly found in your bloodstream, and in doing so dramatically extends the half-life of the peptide: After a single injection of CJC-1295, there were dose-dependent increases in mean plasma GH concentrations by 2- to 10-fold for 6 d or more and in mean plasma IGF-I concentrations by 1.5- to 3-fold for 9 11 d