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The design of these compounds mainly involves the replacement of the metal ion with rhodium, nickel, or zinc, or may have an inactive ligand attached, such as 4-ethylphenyl

Gastrointestinal effects are the most common and include nausea, vomiting, diarrhea, and constipation

The only way a B12 supplement contributes to weight loss is if the person was previously experiencing a B12 deficiency and the metabolic slowdown or fatigue caused by this deficiency is addressed