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Different mechanisms are pro-posed to explain curcumin's effect on glucose homeostasis, which are mainly based on the activation of the gamma receptor, which is activated by the peroxisome proliferator (PPAR-y)

This is the question that most clinicians do not raise proactively and most patients do not think to ask

Addison's Disease Hyperpigmentation On Tongue Addison's disease - primary adrenal insufficiency - is one of the most clinically significant causes of tongue hyperpigmentation because the oral finding can be a visible clue that leads directly to a life-changing (and potentially life-saving) diagnosis

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