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On top of that, genetics predispose some people to having excess weight. GLP-1 medications have the potential to usher in much-needed nuance in how Americans understand obesity

They slow down gastric emptying, increase satiety, and suppress hunger signals from your brain

Key Preclinical Study (Neelakantan et al., 2018): Treatment in diet-induced obese mice produced progressive body weight loss, reduced white adipose tissue mass and adipocyte size, decreased total cholesterol, and no changes in food intake effects were metabolic, not appetite-driven

Retatrutide already produced 28.7% weight loss at 68 weeks on its own