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Oral administration creates slower absorption with sustained but lower peak concentrations due to first-pass metabolism, which may reduce the need for daily dosing as the compound remains bioavailable for extended periods

Hertzman reported that ten patients who suffered from hypertension and mood disorders (major depressive disorder or bipolar disorder) had improved mood with a combination of antidepressants and lisinopril, and no serious negative effects were reported by any of these patients while using lisinopril (209)

Biofactors 49 (1), 3261 (2023)