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All patients improved but the results were more profound for Stage 2 patients b

IGF-1 IGF-1 was first identified in 1957

In ovarian stromal cells of PCOS patients, LH enhances CYP17A1 phosphorylation via the cAMP/PKA pathway, upregulating 17-hydroxylase and 17,20-lyase activities and leading to excessive production of androstenedione and testosterone ( Moreover, excessive LHCGR activation may trigger premature luteinization of granulosa cells through ERK1/2-mediated phosphorylation, disrupting dominant follicle selection

Whether the migraine benefits persist over years, whether tolerance develops, whether discontinuation causes rebound migraines, these are all open questions