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Several factors affect how the skin responds, including: Age Genetics Sun exposure Smoking history Collagen production Amount of weight lost Speed of weight loss For patients with mild skin laxity, non-surgical treatments may help stimulate collagen and improve skin quality

Topical hyaluronic acid is generally safe during pregnancy, while injectable forms should be avoided

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[10] [11] Based on data from retatrutide clinical trials (NEJM, 2023) and experience with similar approved agents, patients may experience: Redness, swelling, or itching at the injection site, which typically resolves within a few hours to days Bruising or mild pain immediately following injection Nodules or localised reactions beneath the skin, which may occur with repeated injections at the same site These reactions are generally mild and self-limiting