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Through its potent properties, it effectively enhances the activity of serum T-SOD, reduces malondialdehyde (MDA) content, alleviates oxidative stress, and exhibits significant anti-rheumatoid arthritis effects (31, 32)

Impaired histamine degradation due to reduced enzymatic activity, particularly involving DAO and histamine-N-methyltransferase (HNMT), can contribute to gastrointestinal and inflammatory diseases

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FIGURE 4 Hence, it is the prevailing recommendation among endocrinologists that non-pregnant individuals with PCOS exhibiting abnormal glucose regulation, irrespective of their body weight status, initiate metformin therapy promptly upon diagnosis, with a prescribed duration of treatment lasting at least 36 months