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129 While the primary endpoints were not met, an unexpected finding emerged four weeks after treatment cessation: patients receiving 50 mg/day of nivalexanil exhibited significantly higher THI scores than placebo recipients, raising concerns about possible rebound effects or symptom exacerbation after withdrawal

Given the above findings, we aimed to review the literature to show the putative potentials of carotenoids against hypertension in preclinical and clinical studies

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