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CoA catabolism produces pantetheine, which vanins, also called pantetheinases, work with to produce pantothenate and cysteamine, the latter of which increases inflammation (122)

Although the direct cytotoxic effects of high cellular GSSG levels have been documented in a variety of cell types 33,34,35,36 , our cell culture studies with hepatocytes revealed that increased GSSG accumulation, despite being non-toxic per se, could sensitize hepatocytes to TNF-induced killing, suggesting that GSSG and TNF can synergistically induce hepatocyte death and that GSSG-triggered sensitization to TNF hepatotoxicity represents a clinically relevant process that may account for disease progression in NAFLD

In: Pagon RA, Adam MP, Bird TD, et al., editors