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Briefly, the preproglucagon gene undergoes tissue-specific post-translational modification with the help of specific propeptidase convertase (PC1/3) to produce two variants of GLP-1, the amidated GLP-1 [736], and the glycine-extended GLP-1 [737] in the ileum and hypothalamus (Zheng et al., 2024)
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In fact, Seltzer has found anecdotally that patients feel more hungry after the effects of semaglutide wear off than they were pre-Wegovy
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