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Clinical therapy of targeting ferroptosis in human diseases Numerous preclinical studies have demonstrated that iron acts as a potent pro-oxidant, contributing to the development and progression of tumors, central nervous system diseases, metabolic diseases, autoimmune diseases, and cardiovascular diseases through the production of highly reactive and cytotoxic free radicals

Its the only GLP-1 medication approved to slow the progression of kidney disease and reduce the risk of cardiovascular death in patients with type 2 diabetes and chronic kidney disease

Some of cancer therapies are based on the sensitivity of cancer cells to oxidative stress, including radiation therapy and many chemotherapeutic agents that enforce oxidative stress and damage products encompassing DNA, lipids, and proteins

8Medications approved for other indications with benefits for MASH8.1Vitamin E Vitamin E has shown efficacy in MASH, including the PIVENS trial that compared Pioglitazone and vitamin E [171]