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The highest-dose period appears to carry disproportionate risk based on pharmacovigilance case series, though prospective data are limited

Most patients see a meaningful decrease in new abscesses and drainage over a full treatment course

It binds within the ERR ligand-binding domain and enhances transcriptional activity at ERR response elements, recruiting coactivators such as PGC-1/

In the NAFLD animal model, hepatic GLP-1R expression levels at the NAFL (8 weeks) and NASH (16 weeks) stages were downregulated, consistent with the data in humans