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2000 Oct;12 Suppl 4:S74-9

Mohammed FS, Ghosh A, Pal S, Das C, Alomar SY, Patwekar M, Patwekar F, Jeon B-H, Islam F

In the simulation of F347, the ligand adopts the same orientation as in the crystal structure, whereas the orientation of the ligand in the simulation of C347 is varied during the simulation process (the trifluoromethyl-pyrazole group in particular)

Conclusion As we see the changes of the OII reorganization take hold within the product centers, we can expect to see continued efficiency in the warning letter process