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Contact your GP if you have dark brown urine persisting despite increased fluids, urine changes with severe vomiting or abdominal pain, signs of dehydration (dizziness, dry mouth, reduced urination), or red/cloudy urine suggesting infection or bleeding

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Among the 25 studies included in the qualitative synthesis (16 in the meta-analysis), 15 focused specifically on serum cobalamin changes (reported by baseline and post-treatment means and standard deviations in pg/mL) and 10 reported homocysteine outcomes (means and standard deviations in mmol/L)

Chichester, UK: John Wiley & Sons, Ltd