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For example, in the DiRECT study of people with obesity and diabetes, very severe caloric restriction leading to a loss of 15% of body weight led to complete remission of type 2 diabetes in 85% of participants

Retatrutide targets all three receptors (GLP-1, GIP, and glucagon) simultaneously, and Phase 2 data showed up to 24.2% weight loss at 48 weeks

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(5.3) Acute Kidney Injury Due to Volume Depletion: Monitor renal function in patients reporting adverse reactions that could lead to volume depletion (5.4) Severe Gastrointestinal Adverse Reactions: Use has been associated with gastrointestinal adverse reactions, sometimes severe