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Key triggers or symptoms of vitamin B12 deficiency are: Tiredness Depression Hair loss Pins & needles Numbness in the hands or feet Tremors or palsies Palpitations Recurrent headaches Dizziness B12 Safety Dosing Standard treatment is to give a loading dose of intramuscular injections of 1mg per 1ml ampoule of hydroxocobalamin every other week for 4 weeks, then inject once every three to four weeks

FDA granted the drug breakthrough therapy designation for the treatment of PBH and congenital hyperinsulinism (HI)

Light chain 3 beta (LC3B, essential for autophagy formation) is an RNA-binding protein that interacts with target mRNAs during autophagy, triggering their rapid degradation 68

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