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As a precaution, tirzepatide should be used with caution in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2

Similarly, the SURMOUNT trials for weight management did not report elevated rates of sore throat compared to placebo

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Symptoms can include chest pain, heart palpitations, and shortness of breath, while electrocardiogram (ECG) changes like tall, "peaked" T waves and a wide QRS complex may be seen