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no therapeutic intervention trials published Cell culture Skeletal muscle myoblasts, cardiomyocytes, endothelial cells, fibroblasts, mesenchymal stem cells Ex vivo tissue preparations Isolated mitochondria, cardiac tissue preparations for respiration studies Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite over 100 published preclinical studies and growing scientific interest, MOTS-c faces substantial translational barriers that limit clinical application and necessitate cautious interpretation of its therapeutic potential
USA 108 , 34653472 (2011)
However it also offers a range of other benefits too
In addition, age dependent accretion of dysfunctional mitochondria elevates stress level, which is exhibited by high levels oxidized products such as protein carbonyls and lipid peroxides 42
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