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Neuroprotection and brain injury repair&Research on metabolic disease models Cerebral ischemia model: After occlusion of the middle cerebral artery (MCAO) in rats, injection of IGF-1 LR3 (10 g/kg) into the lateral ventricle can: Reduce the area of neuronal death by 30%

Drug Discov Today 15:4056

Microglia M1 activation is accompanied by a metabolic shift from oxidative phosphorylation to glycolysis to support the rapid production of pro-inflammatory cytokines (Wilkinson and Landreth, 2006)