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This release leads to increased vascular permeability, plasma protein extravasation, white blood cell infiltration, vasodilation, mast cell breakdown, stimulation of meningeal pain receptors, and further release of inflammatory substances (10)

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In addition, the betanin could inhibit low-density lipoprotein (LDL) and lipid membranes peroxidation because of its bioactive composition, modulating ROS production and gene expression to reduce the inflammatory release of cytokines and increase antioxidant enzyme activities (183)