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51 However, subdiaphragmatic vagotomy had no effect on GLP-1-induced acute activation of PKA in the brain, indicating that the vagus nerve is not involved in GLP-1RAs entering the brain

Afterward, they are stored in the gallbladder, released into the intestinal lumen after a meal, and further metabolized by the gut microbiota into secondary bile acids

It helps control appetite, blood sugar, and digestion