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Despite these established actions, key unresolved questions persist, including: (1) the precise reasons for variable patient response, (2) the mechanism by which lithium's multiplicity of targets converges on a specific therapeutic outcome, and (3) the physiological boundary between lithium's neuroprotective and potential neurotoxic effects, which are critical gaps addressed throughout this review

On the other hand, the occludin-null females produced litters normally when mated with WT males but they did not suckle them

Side effects and how to manage them KLOW is generally well-tolerated, but side effects can occur, particularly during the introduction phase or after dose increases

In addition, vitamin D increased neuromuscular function in parkinsonian rodents (Holick, 2007)