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Garca-Beccaria and coworkers identified two small molecules from a phenotypic screen that decreased TRF1 nuclear localisation, although it is not known whether these bind TRF1 directly 1

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One of the primary pathways leading to caspase activation involves the death receptor pathway, where receptors such as Fas/CD95, following stimulation by FasL, recruit adapter proteins like FADD to initiate the activation of procaspase-8 [160]