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Other causes of inadequate central stimulation include structural lesions of the hypothalamus or pituitary (tumor, surgery, trauma), genetic defects (Kallmann), syndromes associated with hypothalamic dysfunction (Prader-Willi syndrome), energy deficit (excessive exercise, anorexia), chronic disease, or medication effect

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Levels of NAD+ naturally decline with age, which largely contributes to age related issues like reduced energy, slower recovery, cognitive decline, and deterioration of appearance and quality of skin

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