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This relationship is clear in the clinical trial data and helps explain why 20 units at a high concentration can produce dramatically worse symptoms than 20 units at a low concentration

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Interestingly, the residues at multiple positions (12, 16, 17, 20, 21, 24 and 28) of the multi-targeting agonists are highly solvent-accessible and of limited contact with GLP-1R, allowing them to employ distinct amino acids from GLP-1 without altering GLP-1R signaling profiles

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