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This increase in testosterone occurred with an increased concentration of omega-3 fatty acids in the membranes of red blood cells, an indicator of the membrane composition of Leydig cells

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In an earlier study, we showed, using an immunocompetent mouse model of endometriosis, generated with intraperitoneal administration ( ip ) of endometrial fragments null for the progesterone receptor interacting protein Krppel-like Factor 9 (KLF9), that high-fat diet (HFD) promoted endometriosis progression in the absence of ovarian dysfunction, insulin resistance, and significant increase in bodyweight (Heard et al., 2016)