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Next, we assessed the requirement of IGF-1 for the induction of cytotoxicity in human primary NK cells

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Thus the dose, timing, and disease-specific inflammatory response are important pharmacological considerations with GSH treatment ( In addition to being a therapeutic target, oxidative stress has been shown to decrease the GSH:GSSG ratio which has proven useful as a clinically accessible, pharmacodynamic biomarker of immune redox tone for conditions such as malignancy (Zitka et al., 2012)

doi:10.1016/j.molmet.2017.03.006