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While mice and rats do not vomit, GLP-1R agonism induces emesis in the musk shrew and is associated with an increase in cFOS staining in the AP, nucleus of the solitary tract (NTS), DMH, VMH, lateral hypothalamus (LH), and PVH that is blocked by GLP-1R antagonism ( Location of the GLP-1R population plays an essential role in satiating versus aversive effects of GLP-1R agonists ( Figure 3 )