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TRT does not directly cause weight loss

American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated with SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: version 2

Reduced calorie intake Significant weight loss Recent clinical studies have shown that some GLP-1 agonists can lead to 1015% body weight reduction, which is remarkable compared to older therapies

Firstly because of the abundance of GLP-1 receptors in the brain, and secondly because the brain and the immune system communicate with all organs in the body (Lunenfeld-Tanenbaum Research Institute)