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Efficacy and Safety Comparison of Liraglutide, Glimepiride, and Placebo, All in Combination With Metformin, in Type 2 Diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 Study

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These variants, defined by allele frequencies exceeding 1% in the population, may not cause overt disease but can modulate enzyme activity, folate status, and susceptibility to complex conditions