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Intermittent fasting from dawn to sunset for 4 weeks upregulates proteins associated with prolonged longevity and DNA repair We observed an average sixfold increase in H2B histone GP levels 1 week after 4-week intermittent fasting compared with the levels before 4-week intermittent fasting

So an effective way to stop the formation of 5-alpha reductase (and reducing DHT) is to Compete with the coenzyme NADPH, or Block NADPH These are two mechanisms of direct 5-alpha reductase inhibition or for the lay person reducing 5-alpha reductase by stopping it from forming

Pollard JD, Quan S, Kang T, & Koch RJ

ARA 290 could lead to help in autoimmune conditions as well