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They face an immune system trying to correct faulty signals as inflammation builds

In OA, however, due to an inflammatory microenvironment and cellular stress, glycolytic flux often becomes further elevated to meet energy demands, while mitochondrial dysfunction may reduce oxidative phosphorylation efficiency ( 3.4.2 Effects of glucose metabolic reprogramming on lipid and amino acid metabolism Reprogrammed glucose metabolism primarily impacts two areas

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All animal procedures were approved by the British Home Office under the UK animals (Scientific Procedures) Act 1986 (Project License number PP7151519 to Dr Aida Martinez-Sanchez, Imperial College London, UK) and from the local ethical committee (Animal Welfare and Ethics Review Board) at the Central Biological Services unit of Imperial College London