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Experimental literature around thymosin 4 motifs includes anti-apoptotic signaling through Akt/PKB, modulation of PTEN-PI3K circuitry, and shifts in cytokine profilesreducing TNF-/IL-6 while supporting IL-10consistent with a transition from a pro-inflammatory state to a more reparative milieu

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( c ) Fourier shell correlation (FSC) for the density map corresponding to the postfusion structure is shown