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More broadly, they challenge the traditional separation between metabolic and psychiatric disease, suggesting peripheral metabolic signals can influence central processes such as motivation and behavior

Until then, the notification said GLP-1 RAs should only be prescribed for their licensed indication, and clinicians should avoid initiating people with T2DM on GLP-1 RAs for the duration of the national shortage

There is some evidence suggesting that weight cycling has no effect on the risk of type 2 diabetes [49], and there is no conclusive evidence that previous weight cycling affects body composition or predisposition to obesity