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Tirzepatide is a dual agonist it hits both GLP-1 and GIP receptors

Some providers who manage both transitions between GLP-1 medications and transitions from traditional appetite suppressants to GLP-1 therapy report that patients who understand the transition timeline and set appropriate expectations have much better adherence and outcomes than those who expect immediate equivalence between the two medication types

Since Zepbound can already cause gastrointestinal side effects like nausea or indigestion, avoiding NSAIDs like ibuprofen can help minimize further irritation

This creates a more guided experience compared to trying over-the-counter supplements without support