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A critical real-world evidence (RWE) appraisal of these cohorts reveals significant limitations

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Moreover, the administration of GLP-1 into the third ventricle, or the GLP-1 (7-36)-amide (iv), activate the HPA axis by increasing adrenocorticotropic hormone (ACTH) [120], AVP [135], and corticosterone (CORT) plasma levels [120,135], in a time-dependent manner, in conscious freely moving and anesthetized rats [121]