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Aggregation induced by enzyme-responsive ligand plays a key role in facilitating the nanoparticles penetration in the bloodbrain barrier and enhances its retention time in brain tumors

Another major question that remains unanswered as yet is that whether switching the normal machinery from eumelanin (which is protective against UV radiation) to pheomelanin (which photosensitizes UV-induced deoxyribonucleic acid damage as observed in cultured human melanocytes) by an external agent for long duration would result in an increased incidence of skin cancers