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These inhibitors effectively hinder downstream pathways such as HDAC/NF-B, S1P-PI3K-Akt-HIF-1, and TLR4/MyD88, reduce pro-inflammatory cytokines (IL-6 and TNF-) and VEGF, suppress synovial hyperplasia and joint damage, and modulate gut microbiota and intestinal barrier function

Correlated with this decrease in GSH levels, we found that the T2DM group also has significantly higher levels of MDA ( Figures 3B, C ) and higher levels of the proinflammatory cytokine IL-6 ( Figure 3D ) than the healthy group

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Alterations in calcium homeostasis can lead to mitochondrial swelling (Mller et al., 2011), resulting in the leakage of Ca 2+ ions from mitochondria