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Beyond these benefits, research has shown that it alters the enzymes that the body uses to metabolize medications and supplements , thereby increasing their bioavailability

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Finally, translational progress is bottlenecked by the lack of strategies to selectively manipulate p53s ferroptosis-regulating activity: activating its pro-ferroptotic function in cancer cells while preserving its anti-ferroptotic role in normal tissues remains a major challenge, and no validated biomarkers exist to predict which tumors will respond to p53-targeted ferroptosis therapies

In research, higher circulating IGF-1 has been associated with an increased risk of certain cancers (such as prostate, breast, and colorectal)