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Additionally, the drug slows down food movement through the stomach and may reduce appetite, thus helping with weight loss

"Clinicians know that most of their GLP-1 patients will eventually stop the medication, and without new habits the weight tends to come back," said Geoff Cook, CEO of Noom

In addition, chemogenetic inhibition of mOFC DRD2 neurons (via hM4Di) significantly alleviated GTN-induced tactile allodynia: both periorbital and hindpaw withdrawal thresholds were increased compared with model mice treated with normal saline, confirming the analgesic effect of inhibiting mOFC DRD2 neurons

Journal of Lipid Research 37, 14361448