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In different cancer types, higher expression and activity, and changes in the localisation, of H 2 S-synthesising and -breakdown enzymes have been observed in cancer specimens or cell models (Table 1), as compared with tumour-adjacent normal tissue or non-tumorigenic cells, and associated with different aspects of cancer development (e.g

Vagotomy in animal studies is said to disrupt the transfer of -synuclein derived from the gut to the CNS, but human observational evidence is inconsistent, with some studies indicating no change in PD incidence and others suggesting a reduced risk following truncal vagotomy (Elfil et al., 2020)

Studies of AD mouse models have indicated that amyloid-beta and tau-related neurodegeneration in the hippocampus, prefrontal cortex, and anterior cingulate cortex are correlated with NPS-like behavioral deficits